منابع مشابه
Apoptotic Pathways in Pemphigus
Pemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis). In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mechanism by which pathogenic IgG induces acantholysis. We review the current literature examining the...
متن کاملReview Mitochondrial apoptotic pathways
Apoptosis or programmed cell death (PCD) is a physiological process characteristic of pluricellular organisms leading to self-destruction of the cell. It is therefore involved in development, homeostasis and host defense. However, a significant difference has been shown between mammalian cell apoptosis and non-mammalian cell apoptosis: mitochondria are implicated only in the former. Execution o...
متن کاملApoptotic Pathways Paper Wraps Stone Blunts Scissors
The mitochondrial pathway, shown in Figure 1A, is triggered by proapoptotic members of the Bcl-2 family, initially by a subset of these called the " BH3-only sub-family " proteins because they possess only one of the Bcl-2 homology (BH) domains. These include Bid, Bim, Harikari, Noxa, and a number of others. In response to environmental cues these proteins engage another set About 2.2 billion y...
متن کاملCadmium renal toxicity via apoptotic pathways.
Cadmium is a nonessential heavy metal and ubiquitous potential environmental pollutant. Although the kidney proximal tubule is an important target for cadmium, the underlying cellular mechanisms of cadmium-induced renal toxicity remain elusive. Numerous studies have demonstrated that cadmium induces apoptotic cell death in various cell types via several apoptotic pathways, including mitochondri...
متن کاملGlutathione depletion in survival and apoptotic pathways
GSH EXTRUSION IN APOPTOSIS Damaged cells opting for apoptosis actively extrude glutathione in the reduced form as an apical event in the apoptotic signaling (Ghibelli et al., 1995; Van den Dobbelsteen et al., 1996). Apoptotic GSH efflux is very rapid and, as a consequence, cells undergo redox imbalance and become susceptible to oxidative stress due to loss of ROS scavenging power (D’Alessio et ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2000
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)00003-9